Five high-level officials at the Centers for Disease Control and Prevention are leaving. The departures were announced Tuesday at a meeting of agency senior leaders.

The departures were announced at a meeting of agency senior leaders. The Atlanta-based CDC has two dozen centers and offices. The heads of five of them are stepping down, and that follows three other departures in recent weeks. This means close to a third of the agency’s top management is leaving or left recently.

The announcements come a day after the White House announced it is nominating Susan Monarez to be CDC director. But it’s not clear how much, if any, influence that had on the leaders’ decision to leave. The Trump administration earlier this month withdrew its nomination of former Florida congressman Dr. David Weldon just before a Senate hearing.